With the changing life style, people in this century get very less time to make them fit & fine. Weight gain has become another prominent problem for the people engaged in professions without physical work. So lot many medicinal methods have been devised by the medicos to deal with this problem. But weight loss drugs usually harm growing brain as apprehended by the researchers. So research is on to find out a suitable therapy to check it.
Drugs of weight loss treatments disrupt wiring needed for brain development at an younger stage of people as per the American researchers. Specially medicos warn about using these medicines for young people & children because it blocks cannabinoid receptors in the brain. So seeing the negative side effects of drugs on hunger control to achieve weight loss, researchers made several attempts to findout alternatives. Recently US researchers found that blocking a single brain enzyme helps short circuiting a key hunger signal which in turn lessen appetite, loss weight & have better blood sugar control. While much more research lies ahead but the finding may lead to new treatments for obesity and diabetes in humans.
This is an important identification in the drug development target that could potentially turn into metabolic triangle of appetite control, weight loss & blood sugar management. In this research the focus was on the enzyme CaMKK2, which plays an important role in appetite stimulation in human beings. It is found in the region of the brain knows as the hypothalamus & it takes its orders from a hormone released in the gut known as ghrelin, which is released when stomach is empty. This ghrelin is responsible to make people hungry & also it makes food more appealing & pleasing.
Hence, by interrupting ghrelin’s activity, it may be possible to tone down the CaMKK2 enzyme’s response to the hunger signal as it is responsible to give pleasure signals to brain regarding food. So by lacking this enzyme people may cut their hunger & stay slim regardless of whether they are on a low-fat or high -fat diet. Many times these fatty foods cause innumerable problems related to obesity. So if this enzyme theory has its way successfully, people can enjoy their food according to their whims & fancies and can control the weight to stay fit & fine simultaneously.